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Discovery: The Life of Jitendra Pant

By Cynthia Adams | Photos by Nancy Evelyn

Pant is a research assistant and doctoral candidate in bioengineering at the University of Georgia. He has already published nine papers in peer-reviewed journals and holds three patents on biomedical technology with applications pending in the U.S. trademark office. Pant keeps a fast pace yet chooses to live deliberately and joyfully.

Ramanagar, Nainital, India, is small by Indian standards, with a population of 42,000. Nainital, a tourist destination with a picturesque lake, is nestled at the base of the Himalayas.

Here, Jitendra Pant’s parents nudged their children toward higher education. The Pants are Kumaoni, a sect including the Brahmins, and one associated with educational achievement.

“My father could not complete his high school after 9th grade,” Pant explains. Likewise, his mother had to end her education early as well. “But my sisters are PhDs and I am doing my PhD.”

One of the Pant daughters became a neuroscientist, another works in fashion and a third is a lecturer in English literature. Jitendra, best known as Jiten to his friends, is the youngest. Naturally outgoing, with a particular fondness for performance and singing, he settled upon a life as a scientist.

Pant completed an undergraduate degree in technology and biotechnology at ICFAI University Dehradun, India, in 2010, and worked in research and development for three years at Biocon Research Ltd, a biopharmaceutical giant. (“Ranked number one in the entirety of Asia, and the top 20 in the world,” he says.) Pant was working on a graduate degree in engineering with specialization in biotechnology from BITS-Pilani University when he applied to UGA to study bioengineering.

In January 2015 he joined the Handa Research Group in the School of Engineering to study under Hitesh Handa. Two years into his doctoral program, he has published research in nine journals, presented papers at three international conferences, and is named on three patents. Pants’ principal investigator and the lab’s namesake is Hitesh Handa.

Handa works in translational research for development of medical device coatings. Translational research, as Pant explains, underscores invention with practical urgency. “It is to bring things to the market as soon as possible. The work is to see if it is going to work for people.” An example is Handa’s development of biomaterials designed to prevent thrombosis and infection, with potential for medical device applications.

“With his experience in biomolecular interactions (atomic force microscope), materials/surface science, polymeric coatings, blood-surface interactions and animal models, his (Handa’s) goal is to bridge the gap between the engineers and clinical researchers,” according to the lab’s website.

Atomic force microscope, or AFM, allows for the mapping of a surface at a nanoparticle level.

Pant describes a variety of biomedical devices, coatings and biocompatible products that Handa’s lab research and develop. Wound dressings which cause an instant blood clot and thus prevent excessive bleeding, are one. Bio-engineered skin is another.

“Bio-engineered, or artificial, skin is made from natural polymers, like alginate, which is extracted from seaweed, or algae,” he explains. “Nitric oxide biodegradable dressings are also being made to be able to kill more bacteria.” Rather than having to later peel off a dressing and cause re-injury, he says their invention differs. “It will slowly disappear from your system, with no side effects towards human cells.”

When not in the lab, Pant divides his time between creative pursuits, dancing, singing, or working on self-realization. Pant believes discipline and motivation are just as important as intelligence in reaching one’s highest potential. He reads biographies of famous people and studies the spiritual traditions of the world, and is now reading the Essential Wisdom of the Bhagavad Gita.

So when shaving accidents happen, has Pant tried slapping some on that razor nick?

He laughs. No, he hasn’t tried that.

In addition, Pant explains that the lab is working on a project that holds great promise as an alternative to antibiotics. “My first work was in biotechnology research, but I didn’t want to lose that experience so I was drawn to apply my prior experience to my current biomedical engineering research. My boss thinks from a material’s perspective. I think from a biological perspective.”

Does this also mean that he is a diligent label reader?

“I definitely read labels for things like triclosan,” Pant replies. Consumer Reports states that triclosan, for example, has been banned from soap, yet triclosan remains in cosmetics and popular toothpaste. (It is under scrutiny for having endocrine disruptive properties and is suspected of affecting the gut biome.)

Pant is health-focused in his own habits. Toward that end, he quit consuming sugar. “It has so many side effects,” Pant says. Nor does he consume artificial sweeteners. “Anything that is synthetic is definitely going to harm you if you eat it.”

He studied endocrine disrupters while in India. Common food and beverage containers may be culprits, such as water bottles, Pant says.

“So when you are drinking this water, you are drinking the chemicals that the bottle leaches too.” He recommends using metallic or glass containers.

Yet, if harmful substances can leach, there is a flip side as well, as Pant observed back home. Copper and zinc tea pots, commonly used in India, are known to have positive effect upon drinking water. Called “Indian brass” this combination is inherently anti-bacterial.

Pant and Handa experimented, combining copper with nitric oxide releasing polymers. “It has anti-bacterial properties. When zinc and copper leach in minute concentrations into your body, they will heal your entire body.”

Last year, Pant published an article on the topic, titled, “Tunable Nitric Oxide Release from S-Nitroso-Nacetylpenicillamine via Catalytic Copper nanoparticles for Biomedical Applications.” He says the article appeared “in a very high impact factor journal, ACS Applied Materials and Interfaces.”

When using the copper and nitric oxide polymers, “You have to use them in Nano quantities on a Nano scale; it can harm you in high dosages,” Pant cautions. “When we used copper in our material, we used concentrations lower than the allowable quantity,” he says. They did testing on mammalian fibroblast cells, ensuring safety before taking it to market.

Also in testing stages is an alternative to antibiotics.

“Antibiotics target bacteria and they can develop resistance against antibiotics very quickly,” explains Pant. “Nitric oxide is produced by the human body to fight against infections and promote a lot of our biological processes. That’s why using nitric oxide based strategies, as we do in our lab, are better than antibiotics.”

Products under development are exhaustively tested for efficacy and safety.

“I started doing things like looking at the cellular and the genetic level,” Pant explains. “I want to know if something is happening in the DNA which is not expressed now but might be later on. The difference with our group is not delivering material without looking at the biotechnological implications. I think this is a change in the way scientists do things. The knowledge gap is being closed.”

“I want to walk the talk,” Pant says. “I left my job in a pharmaceutical company because I wanted to get my PhD… I want to make a difference.” The public benefits from different research perspectives and inter-disciplinary approaches.

Putting speaking skills to the test at the 3MT

In Pant’s perspective, to be successful requires focus. For the first year and a half after arriving at UGA, Pant did not take a single day off.

“I worked like crazy,” he admits. “And I sometimes left the lab at 1:00 or 2:00 a.m. I did nothing but work.” More recently, he began to rise at 5:00 a.m. He did this to be more disciplined and accomplish more.

Pant’s industry has paid off. Last April, He competed in 3MT, or the Three Minute Thesis, at Cine Theater in Athens. Condensing his work into three minutes and one static slide, he presented on one of his lab’s projects: the creation of artificial skin to aid burn victims.

“1.1 million people in the U.S. alone are serious burn victims,” Pant explained. “Not everyone can bear the cost of plastic surgery.” Bio-engineered artificial skin would not only benefit patient healing but potentially prevent disfigurement, even without the aid of plastic surgery.

The audience included 27 of Pant’s friends, eight from the Student Toastmasters chapter, cheering for him. (“I think people here are very, very nice,” Pant confessed later.) The Three Minute Thesis was where their friend, Jiten, would put to test what they were mutually learning, but with unusually stiff pressures.

Pant had begun attending Toastmasters in order to hone his speaking skills four months earlier, all in hopes of winning the Toastmasters International World Champion of Speaking title. (“One day,” he emails later. “In the long run, I want to be a successful leadership and life coach.”) It stood him in good stead as preparation for the 3MT. The Toastmasters group met on Mondays at 5:30 p.m. weekly for an hour and a half of public speaking practice and rehearsals at the Miller Learning Center. In typical fashion, Pant wanted to leave nothing to chance.

As the judges weighed in on April 8th after the 3MT, the contestants and their guests gathered at an after-reception inside the theater. As usual, it was an impressive group of graduate students and the judges were to single out only two winners. He won an unofficial third place in the competition.

If Pant was disappointed to learn that evening that he did not win first place in the competition, it did not show. As his girlfriend and friends enthusiastically clapped him on the back afterward, Pant smiled. He had already earned fellow Toastmasters highest praise: during his speech he had used no filler words, no awkward “ums” nor “ahs” (all of which are discouraged by Toastmasters) and never once did he stumble.

Pursuing Joy

Pant hits the gym, then showers and cranks up the music. “Sometimes I play Bollywood music or anything to which I can dance.” The pre-dawn hours are a golden window of time for play, for Pant is a student of “the art of fulfillment.” In his words, “I firmly believe that you do not sing because you are happy, you are happy because you sing.”

Pant dove into self-awareness and self-actualization with gusto, learning to shoot pool and read novels simply for pleasure. He posts his singing performances, like one recorded in Helen, Ga., on YouTube.

He is now an officer serving as the secretary of his Toastmasters club. After all, it is where he discovered that his natural penchant for talking was a strength. In giving motivational speeches, something he likes to do when in India, he puts his ideas to practice. “A PhD is the highest academic degree I can get,” Pant says. “If that is where I am happier, I will focus there. I am writing a novel, and if that is where I am happiest, I will focus there.”

The path is open; at age 28, Pant has world enough, and time.

For further reading:

For Pant’s 2017 3MT presentation:

 

Pant’s website is: http://jitendrapant.com/ 

The Essential Wisdom of the Bhagavad Gita is at: https://www.amazon.com/Essential-Wisdom-Bhagavad-Gita-Ancient/ dp/1577315294

This story originally appeared in UGA Graduate, the magazine of the University of Georgia Graduate School.

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